肝臟星形細胞是小葉內結締組織細胞，呈現肌成纖維細胞樣或脂肪細胞形態。他們參與肝臟細胞外基質的穩態，修復，再生，纖維化以有控制視黃醇的代謝，存儲和釋放。肝臟受傷后，肝臟星形細胞轉化成肌成纖維細胞樣，并且是纖維化的肝臟中 I 型膠原的主要來源。除了以上特征，已發現在疾病狀態和肝內門靜脈高壓的發病過程中，肝星狀細胞通過細胞收縮調節肝臟微循環[1,2]。星形細胞的增殖、遷移和趨化因子的表達參與了肝臟炎癥和纖維化的發病過程。因此，星形細胞激活的分子調控在將來有助于治療肝纖維化，并且能減少慢性肝病患者的發病率和死亡率。
Sciencell研究實驗室的人肝星形細胞是從人肝臟組織中分離得到的，原代凍存，冰凍運輸。每管細胞密度超過5×10^5/ml。人臍靜脈平滑肌細胞經desmin 和α-actin免疫熒光鑒定。本細胞經檢測不含HIV-1、HBV、HCV、支原體、細菌、酵母菌和真菌。如采用ScienCell 實驗室特制的培養基，可保證此細胞15倍增增殖。? ?
推薦培養基：星形細胞培養基?(SteCM, Cat. #5301)
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貨號
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5300
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產地
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美國
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縮寫
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HHSteC
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規格
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5 x 10^5 /1ml
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用途
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科研
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儲存
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液氮
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運輸
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干冰
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關鍵字
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人肝星形細胞 HHSteC 人肝星形細胞 HHSteC 人肝星形細胞 HHSteC 人肝星形細胞 HHSteC 人肝星形細胞 HHSteC 人肝星形細胞 HHSteC
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公司簡介
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合肥星肽生物科技有限公司作為專業的ScienCell中國代理商，專業經營實驗室科研用原代細胞、原代細胞專用培養基、原代細胞無血清培養基、干細胞、干細胞培養基、干細胞無血清培養基的研究和開發。合肥星肽生物科技有限公司始終致力于為客戶提供可靠的研究材料以及方便快捷的服務，對購買項目的前期資料提供,中期合同保證,后期貨物跟蹤到 *終售后的確保項目準確到位，都有相關專業人士進行維護,確保您在合肥合肥星肽生物科技有限公司公司獲得*上等服務！
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聯系方式
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何經理，合肥星肽生物科技有限公司，Tel：0551-63802898 400-8702-898，
E-mail：info@qingbio.com http://www.huangyuansheng.cn QQ:514713116
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1.) Wagner I,?Materne EM,?Brincker S,?S??bier U,?Fr?drich C,?Busek M,?Sonntag F,?Sakharov DA,?Trushkin EV,?Tonevitsky AG,?Lauster R,?Marx U. (2013) "A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture."?Lab Chip. doi: 10.1039/c3lc50234a
2.) Yamana D, Shimizu T, Fan Y, Miura T, Nanashima N, Yamada T, Hakamada K, Tsuchida S. (2011) "Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis."?Cancer Sci. 102: 735-41.
3.) Das A, Shergill U, Thakur L, Sinha S, Urrutia R, Mukhopadhyay D, Shah VH. (2010) "Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment."?Am J Physiol Gastrointest Liver Physiol. 298: G908-15.?
4.) Hozawa S, Nakamura T, Nakano M, Adachi M, Tanaka H, Takahashi Y, Tetsuya M, Miyata N, Soma H, Hibi T. (2008) "Induction of matrix metalloproteinase-1 gene transcription by tumour necrosis factor alpha via the p50/p50 homodimer of nuclear factor-kappa B in activated human hepatic stellate cells."?Liver Int. 28: 1418-25.?
5.) Mart?n-V?lchez S, Sanz-Cameno P, Rodr?guez-Mu?oz Y, Majano PL, Molina-Jim?nez F, L?pez-Cabrera M, Moreno-Otero R, Lara-Pezzi E. (2008) "The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells."?Hepatology. 47: 1872-83.
6.) Semela D, Das A, Langer D, Kang N, Leof E, Shah V. (2008) "Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function."Gastroenterology. 135: 671-9.
7.) Shimamura T, Fujisawa T, Husain SR, Kioi M, Nakajima A, Puri RK. (2008) "Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model."?J Immunol. 181: 4656-65.
8.) Che J, Chan ES, Cronstein BN. (2007) "Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling CAS:cade or p38 mitogen-activated protein kinase signaling pathway."?Mol Pharmacol. 72: 1626-36.
9.) Perri RE, Langer DA, Chatterjee S, Gibbons SJ, Gadgil J, Cao S, Farrugia G, Shah VH. (2006) "Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation."?Am J Physiol Gastrointest Liver Physiol. 290: G535-42.
10.) Brown KE, Broadhurst KA, Mathahs MM, Brunt EM, Schmidt WN. (2005) "Expression of HSP47, a collagen-specific chaperone, in normal and diseased human liver."?Lab Invest. 85: 789-97.
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