心臟成纖維細胞為心肌細胞提供結構支持，并負責在生長和病理生理條件下心肌細胞外基質的合成。CF是心肌損傷反應的重要細胞成分和旁分泌生長因子的來源。CF的增殖和基質合成對于心肌梗塞、心肌纖維化部位瘢痕形成具有重要作用。CF的培養已被廣泛應用為生理（運動）和病理（高血壓）應激下心臟基質重塑研究的模型。CF的培養已被廣泛應用為生理（運動）和病理（高血壓）應激下心臟基質重塑研究的模型。CF通過間隙連接施加電緊張，影響心肌細胞的電耦合性形式。這些電耦合被認為在心房復雜的分流電描位點發生中起重要作用，因此是研究房顫的一個**模型。
Sciencell研究實驗室的HCF-aa是從人胎兒心房分離得到的，原代凍存，冰凍運輸。每管細胞密度超過5×10^5/ml。細胞特性經纖維粘連蛋白免疫熒光鑒定。本細胞經檢測不含HIV-1、HBV、HCV、支原體、細菌、酵母菌和真菌。如采用ScienCell 實驗室特制的培養基，可保證此細胞15倍增增殖。
推薦培養基：內皮細胞培養基 (HM, Cat. #2301)
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[2] Akiyama-Uchida Y. (2002) ?Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.? Hypertension. 40: 148-54.
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